Blockade of specific NOTCH ligands: a new promising approach in cancer therapy.
نویسندگان
چکیده
SUMMARY The signaling specificity conveyed by distinct combination of NOTCH receptors/ligands has remained elusive. In this issue of Cancer Discovery, through the development of ligand-specific NOTCH inhibitors, Kangsamaksin and colleagues uncovered unique signaling outcomes downstream of DLL- and JAG-receptor activation and demonstrated their effects in the suppression of tumor angiogenesis.
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ورودعنوان ژورنال:
- Cancer discovery
دوره 5 2 شماره
صفحات -
تاریخ انتشار 2015